Precocious puberty means that a child is starting puberty early. Breast development is an early sign in girls, for whom precocious puberty is much more common than boys. Experts are studying possible causes of early puberty, including genetics, body fat, and exposure to certain chemicals. Crossing this milestone ahead of time can be challenging for girls and parents. Talk with your child's doctor if your daughter is showing signs of precocious puberty before age 8.
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Precocious puberty means that a child is starting puberty early. It's usually defined as puberty before age 8 in girls. (Boys can also experience early puberty, though it happens to girls about 20 times more often. Early puberty for boys is defined as puberty before age 9.)
Uldbjerg CS et al 2022. Prenatal and postnatal exposures to endocrine disrupting chemicals and timing of pubertal onset in girls and boys: A systematic review and meta-analysis. Human Reproduction Update. [Accessed June 2022]
HIV is now known to spread between CD4+ T cells by two parallel routes: cell-free spread and cell-to-cell spread, i.e. it employs hybrid spreading mechanisms.[95] In the cell-free spread, virus particles bud from an infected T cell, enter the blood/extracellular fluid and then infect another T cell following a chance encounter.[95] HIV can also disseminate by direct transmission from one cell to another by a process of cell-to-cell spread.[96][97] The hybrid spreading mechanisms of HIV contribute to the virus's ongoing replication against antiretroviral therapies.[95][98]
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